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In a group of drugs against hypertension: antihypertensive agents
High blood pressure, known medically as hypertension, is a worldwide health problem and is considered an important risk factor for cardiovascular diseases such as heart attack, stroke and kidney failure. For the treatment of hypertension various pharmacological substance groups, which are as antihypertensive agents known. Their mechanism of action aims to reduce the blood pressure to a healthy value of less than 140/90 mm Hg (or 130/80 mmHg in high-risk patients).
The main groups of antihypertensive agents
ACE inhibitors (Angiotensin‑converting enzyme inhibitor)
Active ingredients such as Enalapril, Ramipril, Lisinopril, inhibit the enzyme, ACE, that for the conversion of Angiotensin I in the blood pressure-increasing Angiotensin II is responsible. As a result, the vasoconstriction is reduced and the blood pressure is lowered. In addition, ACE inhibitors offer a protective effect for the heart and kidneys, particularly in patients with Diabetes mellitus.
AT1‑receptor blockers (Sartans)
To belong to this group, Losartan, Valsartan, and Candesartan. They block the Angiotensin II receptors type AT1, which is also a vasodilation and reduction in blood pressure is achieved. AT1 receptor blockers are often used as an Alternative in patients who are ACE inhibitor because of a disturbing cough is not tolerated.
Calcium antagonists
These drugs (e.g., amlodipine, nifedipine, Verapamil) inhibit the influx of calcium ions (Ca
2+
) in the smooth muscles of the blood vessels and the heart. Due to the Relaxation of the vascular walls, it comes to a vasodilation and thus to a decrease in peripheral vascular resistance and blood pressure.
Beta-blockers
Substances such as Metoprolol, Bisoprolol or Carvedilol act through the Blockade of β‑Adrenoceptors. You decrease the heart rate and cardiac output, which leads to a reduction of the systolic blood pressure. Beta-blockers are particularly recommended after a myocardial infarction or in heart failure.
Diuretics (Diuretics)
Thiazides (eg, hydrochlorothiazide) and loop diuretics (e.g., furosemide), promote the excretion of water and salt through the kidneys. As a result, the blood volume and the blood decreases, pressure decreases. Diuretics are considered to be a cornerstone of hypertension treatment, especially in elderly patients.
Aldosterone antagonists
Spironolactone and Eplerenone inhibit the mineralocorticoid receptor and thus the action of aldosterone. This leads to increased excretion of sodium and water, as well as a well-preserved potassium levels. They are mainly used in patients with heart failure and resistant hypertension.
Therapeutic Approach
The us, the individual risk profiles, and monitoring the treatment is started disorders, usually with a drug. In case of inadequate control of blood pressure with a combination therapy, often made up of two classes of substances (e.g., ACE inhibitor + calcium antagonist or the AT1‑receptor blocker + diuretic) follows.
Side effects and contraindications
Each group of antihypertensive agents has specific side-effect profiles:
ACE‑inhibitors: cough, Hyperkalemia, angioedema
AT1‑receptor blocker: Hyperkalemia (rare cough)
Calcium Antagonists: Edema, Redness Of The Face
Beta-blockers: bradycardia, bronchospasm (non‑selective)
Diuretics: Electrolyte Disturbances (Hypokalemia), Hyperuricemia
Before therapy contraindications (e.g. pregnancy at ACE are to be clarified inhibitors and Sartans), as well as interactions with other medications.
Conclusion
The us of the diversity of the antihypertensive agents can be adapted to the treatment individually. An early and effective lowering blood pressure reduces the risk of cardiovascular complications and improves the quality of life and expectation of the parties Concerned. Regular controls, and patient training is of Central importance.
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Ang pagkontrol sa presyon ay isang napakahalagang gawain, dahil ang pag-inom ng mga tableta na nakakatulong sa pagpapanatili ng normal na mga indikador ay maaaring magbigay ng araw-araw na komportableng buhay, upang maiwasan ang panganib ng hypertensive crisis, atake sa puso, at stroke. Ang mga gamot para sa kontrol ng presyon ay medyo malawakang makukuha sa mga botika, pero tanging ang doktor lang ang makakapili ng tamang gamot na angkop sa therapy. Lahat ng grupo ng gamot para pababain ang presyon ay may iba't ibang mekanismo ng epekto, side effects, at may kaunting posibilidad ng pagkadepende. Ang tamang pagpili ng gamot ay nagbibigay ng mabilis at tuloy-tuloy na resulta, at ang eksperimento sa sarili sa pag-inom ng gamot ay may mataas na posibilidad ng biglaang karamdaman, sakit sa puso at daluyan ng dugo, at sa matinding kaso, maaaring magdulot ng kamatayan. Cardiovascular disease CVD causes. The treatment of cardiovascular diseases in the sanatoria Germanys. Tablets of hypertension prices. Factors of cardiovascular diseases. A sedentary lifestyle, alcohol, and cigarette consumption increase body weight which in turn hinders healthy blood circulation and strength of arteries and veins. This results in high blood pressure. So, if you’re overweight, you need to monitor your blood pressure frequently.
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