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A medicine against high blood pressure: Lorista (Losartan) 5 mg
Introduction
High blood pressure (arterial hypertension) is one of the most common cardiovascular disease worldwide and a major risk factor for heart attacks, strokes and kidney disease. An effective pharmacological therapy is crucial for the prevention of these complications. An important drug in the treatment of hypertension is Lorista, whose active substance is Losartan.
Pharmacological classification and mechanism of action
Losartan belongs to the group of Angiotensin II receptor antagonists (AT₁ receptor blocker). The active ingredient in the binding of Angiotensin II binds to its receptors, in particular of the AT₁ receptors in blood vessels, heart, and kidney. This is achieved in the following:
Vasodilatation (enlargement of blood vessels);
Reduction of peripheral vascular resistance;
Reduction in Aldosterone secretion;
less Retention of sodium and water in the body;
protective effect on the heart and kidney.
Composition and dosage form
Lorista 5 mg is in the Form of tablets, with a plant-based casing covered. Each tablet contains:
Active ingredient: Losartan potassium 5 mg;
Auxiliary substances: lactose monohydrate, Microcrystalline cellulose, maize starch, povidone K30, Colloidal silicon dioxide, magnesium stearate, talc, Croscarmellose sodium (exact composition can vary from manufacturer to manufacturer).
Indications
The medical regulation in accordance with Lorista 5 mg is used in the following diseases:
Arterial hypertension as monotherapy or in combination with other antihypertensive agents.
Renal protection in patients with type 2 Diabetes mellitus and proteinuria to slowing the progression of kidney disease.
Reduction in the risk of stroke and heart attack in patients with hypertension and left ventricular hypertrophy.
Dosage and administration
The dosage is determined individually, and should always be done under medical supervision.
The standard dose for hypertension: 50 mg once daily. If necessary, the dose may be increased to 100 mg per day.
Starting dose (e.g. in the case of volumver reduction or concomitant intake of diuretics): 12.5 mg daily, gradually increased.
The tablet is swallowed whole, with or without food, at the same time of day taken.
Contraindications
Lorista should not be used in:
Pregnancy and breastfeeding (can cause damage to the fetus);
Age under 18 years (a lack of data on safety);
Hypersensitivity to Losartan or to any of the excipients;
severe liver disease;
Combination with Aliskiren in patients with diabetes;
hereditary intolerance of Lactose (if included).
Side effects
Possible side effects (depending on frequency):
Common: dizziness, fatigue, Hyperkalieämie (elevated potassium levels), gastrointestinal complaints (Nausea, diarrhea).
Uncommon: Headache, Sleep Disorders, Cough, Edema.
Rare: allergic reactions (urticaria, angioedema), renal dysfunction.
Upon the Occurrence of serious side effects, consult a physician.
Interactions with other drugs
Losartan may interact with other medicines inter:
Potassium-sparing diuretics, potassium supplements, increase the risk of a Hyperkalieämie.
NSAIDs (e.g., Ibuprofen): may diminish the antihypertensive effect and renal function compromise.
Other blood pressure lowering drugs: additive effect, possible hypotension.
Conclusion
Lorista (Losartan 5 mg) is a modern, effective and relatively safe drug for the treatment of hypertension and for the prevention of cardiovascular complications. The therapy should be individually tailored and under regular medical control. Before the beginning of the treatment, a careful medical history and, if necessary, laboratory tests (potassium, renal function) are required.
Note: This Text is for information purposes only and does not replace the medical advice. Before taking Lorista a doctor must be consulted.
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Ang presyon ng dugo ay isa sa mga pangunahing indikasyon ng kalusugan, na hindi lamang sumasalamin sa puso at sistema ng sirkulasyon, kundi pati na rin sa aktibidad ng mga bato, mga organo ng endokrin, paggawa ng dugo, at ng sistema ng nerbiyos. Kaya naman, walang isang unibersal na gamot laban sa mataas na presyon ng dugo. Hindi ka basta basta puwedeng pumunta sa botika at magtanong ng 'tableta para sa presyon,' kasi agad na tatanungin ng parmasyutiko – anong gamot ang nireseta sa iyo ng doktor? Ang mga modernong gamot sa pag-imprenta ay hinahati sa 10 iba't ibang grupo ayon sa kanilang mekanismo ng pagkilos. Pagkatapos suriin ng doktor ang mga reklamo ng pasyente at ang resulta ng mga pagsusuri, nagrereseta siya ng isa o higit pang gamot, na hindi dapat baguhin nang mag-isa. Ang mga gamot sa puso at daluyan ng dugo ay hindi kabilang sa mga puwedeng irekomenda sa kaibigan. Ang maling desisyon ay maaaring magdulot ng malungkot na kahihinatnan. Lahat ng gamot na pampababa ng presyon ng dugo ay kailangan ng reseta. Sa artikulong ito, tinitingnan natin ang kanilang modernong klasipikasyon base sa mga aktibong sangkap at sa paraan ng epekto nito sa katawan.