✅ Atherosclerosis of the heart vascular diseases
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Investigation of diseases of the cardiovascular System.
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Atherosclerosis as a cause of cardiovascular disease
Atherosclerosis, also known as vascular calcification referred to, is one of the most important causes of cardiovascular disease (CVD) in industrialized countries. This chronic disease is characterized by a progressive change in the vessel walls, in particular, of the arteries, which leads to a stiffening and narrowing of the vessel lumen.
Pathophysiology
The core process of atherosclerosis, the formation of atherosclerosis‑Placken (Atheromas) is on the inside of the artery walls. The process typically begins with damage to the endothelium — the innermost cell layer of the blood vessels. Factors such as high blood pressure (hypertension), high concentrations of low-density Lipoprotein (LDL, bad cholesterol), Smoking, and Diabetes mellitus can cause this injury.
After the damage to LDL particles to penetrate into the vessel wall and become oxidized. This triggers a local inflammatory reaction: monocytes migrate into the vessel wall, in order to differentiate to macrophages and oxidized LDL. By Overloading it with lipids, so-called foam cells, which form the core of the early Plaque arise.
With time, collagen, calcium, and other substances are deposited in the area of the Plaque. The Plaque grows and narrows the vessel lumen, what is the blood supply restricting the supplied organs. A particularly dangerous complication is the instability of the Plaque: In case of a rupture of the plaque ceiling, it can lead to thrombus formation (blood clot), which can occlude the vessel quickly and completely.
Clinical effects on the cardiovascular system
The hand-ment of atherosclerosis varies depending on the affected artery:
Coronary arteries (coronary arteries): narrowing lead to a reduced oxygen supply to the heart muscle (the myocardium of ischemia). Symptoms may include Angina pectoris (chest pain at the time of load). A complete closure caused by a myocardial infarction.
Cerebral vessels Atherosclerotic changes in the arteries of the brain, the risk for a stroke (apoplexy) increase as a result of thrombosis or embolism.
Peripheral arteries: in Particular, the leg arteries are affected (peripheral arterial disease, pad). A typical Symptom is claudication (intermittent Klaudikation) is — calf cramps when walking, the decay stay again.
Aorta: aneurysms (Bulges) of the Aorta, especially of the abdominal aortic section, are often due to atherosclerotic processes and represent the risk of a tear (rupture) a life-threatening Situation.
Risk factors
One distinguishes between modifiable and non-modifiable risk factors:
Non-modifiable: age, male gender, family history.
Modifiable: hypertension, hyperlipidemia (elevated cholesterol), Diabetes mellitus, Smoking, Overweight/obesity, lack of physical activity, unhealthy diet.
Prevention and therapy
Effective prevention of cardiovascular disease due to atherosclerosis is based on the influence of modifiable risk factors:
Style changes: Smoking cessation, healthy diet (e.g., Mediterranean diet), regular physical activity, weight reduction in Overweight life.
Drug Therapy:
Cholesterol-lowering drugs (statins) to reduce the levels of LDL‑cholesterol;
Blood pressure lowering in hypertension;
Hypoglycemic agents in Diabetes mellitus;
antiplatelet drugs (e.g. aspirin) to prevent thrombus.
Interventional and surgical procedures: In the case of advanced narrowing of the procedures such as balloon dilatation with stent implantation (PTCA) or Bypass surgery are used.
Summary
Atherosclerosis is a multifactorial, chronic process that forms the basis for most of the cardiovascular diseases. A comprehensive understanding of the pathophysiology and the risk factors is essential for the Primary and secondary prevention. Through a combined strategy of health-promoting life-style, and goal-directed medical therapy, the incidence and risk of complications can be significantly reduced.
Ang pagkontrol sa presyon ay isang napakahalagang gawain, dahil ang pag-inom ng mga tableta na nakakatulong sa pagpapanatili ng normal na mga indikador ay maaaring magbigay ng araw-araw na komportableng buhay, upang maiwasan ang panganib ng hypertensive crisis, atake sa puso, at stroke. Ang mga gamot para sa kontrol ng presyon ay medyo malawakang makukuha sa mga botika, pero tanging ang doktor lang ang makakapili ng tamang gamot na angkop sa therapy. Lahat ng grupo ng gamot para pababain ang presyon ay may iba't ibang mekanismo ng epekto, side effects, at may kaunting posibilidad ng pagkadepende. Ang tamang pagpili ng gamot ay nagbibigay ng mabilis at tuloy-tuloy na resulta, at ang eksperimento sa sarili sa pag-inom ng gamot ay may mataas na posibilidad ng biglaang karamdaman, sakit sa puso at daluyan ng dugo, at sa matinding kaso, maaaring magdulot ng kamatayan.
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