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Drugs against hypertension without side effects: a critical review
High blood pressure (arterial hypertension) is one of the most common chronic diseases worldwide and a major risk factor for cardiovascular disease, stroke, and kidney damage. Pharmacotherapy is one of the most important treatment strategies. However, the side effect profile of antihypertensive agents is often a challenge, which can interfere with the therapy adherence.
Current groups of Drugs and their side effects
The most commonly used drugs for the treatment of high blood pressure include:
ACE inhibitors (eg, Lisinopril): typical side effects cough, Hyperkalemia, and in rare cases of angioedema.
AT1‑receptor blockers (e.g., Losartan): less likely to cause cough than ACE‑inhibitors, however, can also cause Hyperkalemia.
Calcium channel blockers (e.g. amlodipine): possible side effects include Edema, redness of the face, and constipation.
Beta-blockers (e.g., Metoprolol) can lead to fatigue, bradycardia, and sexual dysfunction.
Diuretics (eg, hydrochlorothiazide): sometimes lead to electrolyte disturbances (hypokalemia), increased uric acid levels, and elevated blood sugar.
There are medications without side-effects?
A complete absence of side effects in the blood-pressure-lowering drugs is not based on current scientific knowledge to be realistic. Each of the pharmacologically active compound that interacts with biological systems and can cause unintended effects.
Nevertheless, there are approaches to minimize the risk and intensity of side effects:
Individual Therapy Adjustment. The choice of the drug should be made on the Basis of Comorbidities, age, ethnicity, and individual risk factors. For example, calcium channel blockers are preferable in patients with Asthma, because they have no broncho konstriktiven effect.
Low Start-Up Doses. The Start of therapy with low doses and gradually increase (start low, go slow) reduces the likelihood of side effects.
Combination therapy with lower doses. The combination of two or more substances in low doses can increase the effectiveness and the side effect rate is lower.
New Drug Classes. Research is ongoing for the development of substances, which are aimed at novel targets, such as:
Endothelin‑receptor antagonists (in development),
Renin inhibitors (such as Aliskiren), which allow a direct inhibition of the Renin‑Angiotensin system.
Non‑pharmacological measures. The style changes (healthy diet to the DASH‑Schema, exercise, weight loss, reduction of salt and alcohol consumption) life can lower the blood pressure and the need for high doses of medicine to reduce.
Conclusion
Drugs that are completely free of side effects, do not exist. However, an individualized approach to therapy, the modern active ingredients and non‑drug measures combined allows for effective blood pressure control while minimizing adverse effects. The future of the hypertension treatment lies in the personalization of medication and the development of new, more selective drugs.
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